منابع مشابه
Heme arginate: effects on hemostasis.
Hematin, the drug used for acute porphyric attacks, has been shown to cause disturbances in hemostasis, mainly because of its degradation products. Lately a new heme compound, heme arginate, has been developed for the treatment of porphyrias. In experimental animal studies as well as in clinical use it has proved to be well tolerated. To find out whether heme arginate has any effects on hemosta...
متن کاملAdministration of Heme Arginate Ameliorates Murine Type 2 Diabetes Independently of Heme Oxygenase Activity
Amelioration of rodent type 2 diabetes by hemin has been linked to increased heme oxygenase (HO) activity, however alternative mechanisms have recently been proposed for its anti-diabetic effect. We sought to determine the anti-diabetic efficacy of heme arginate (HA), a clinically licensed preparation of heme, and whether its predominant mode of action is via increased HO activity. Intravenous ...
متن کاملEffect of heme arginate administration on blood pressure in spontaneously hypertensive rats.
Cytochrome P450 content and activities are increased in the kidneys of spontaneously hypertensive rats (SHR) as compared with those of normotensive, Wistar-Kyoto (WKY), control rats during the period of rapid elevation of blood pressure. We studied the effect of heme arginate, a potent inducer of heme oxygenase (EC 1.14.99.3), on microsomal cytochrome P450 levels and activities and blood pressu...
متن کاملHematin: Unique Effects on Hemostasis
Hematin is clincally useful in the treatment of acute intermittent porphyria. Recently, hematin-induced coagulopathy has been reported. and a patient we treated bled during hematin therapy. On 3 separate occasions. infusions of hematin (4 mg/kg) induced thrombocytopenia, prolongation of the prothrombin time, partial thromboplastin time. Reptilase time and apparent decreases in fibrinogen and in...
متن کاملHEMOSTASIS, THROMBOSIS, AND VASCULAR BIOLOGY Pro-oxidant and cytotoxic effects of circulating heme
Numerous pathologies may involve toxic side effects of free heme and hemederived iron. Deficiency of the hemecatabolizing enzyme, heme oxygenase-1 (HO-1), in both a human patient and transgenic knockout mice leads to an abundance of circulating heme and damage to vascular endothelium. Although heme can be directly cytotoxic, the present investigations examine the possibility that hemoglobin-der...
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ژورنال
عنوان ژورنال: Blood
سال: 1988
ISSN: 0006-4971,1528-0020
DOI: 10.1182/blood.v71.3.625.bloodjournal713625